仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用. Teprotumumab is an IGF-1 receptor （IGF-1R） blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research